Figure 4. Potential interaction of new ligands with the RNA-binding groove of Ebola virus NP.
(A) The crystal structure of EBOV NPcore containing the N-lobe (in blue) and C-lobe (in brown). The RNA-binding pocket surrounded by several residues is marked by a circle and enlarged in the side stereoview. (B) Primary sequence alignment of members of the filoviridae family. Residues in the RNA-binding groove are indicated by yellow arrows. Docking model of GC7 (C) and GC13 (D) interacting with the RNA-binding groove of EBOV NP.