Table 5.

Survival under specific treatments

		Exon 4 intensity				Exon 4 %				OPN-c intensity				OPN-c %
Treatment	n	Odds ratio	95 % CI	p-value	Supre-mum test	Odds ratio	95 % CI	p-value	Supre-mum test	Odds ratio	95 % CI	p-value	Supre-mum test	Odds ratio	95 % CI	p-value	Supre-mum test
hormone no (all subgroups)	54	0.503	0.287-0.881	0.016	0.104	1.087	0.624-1.895	0.767	0.908	0.620	0.353-1.089	0.096	0.178	1.210	0.696-2.102	0.500	0.954
hormone yes (all subgroups)	65	0.657	0.381-1.134	0.131	<.0001	0.687	0.391-1.206	0.191	0.056	0.826	0.463-1.473	0.517	0.005	1.101	0.630-1.923	0.735	0.704
hormone alone	18	1.534	0.430-5.467	0.509	0.614	1.122	0.420-2.998	0.819	0.616	1.661	0.607-4.542	0.323	0.518	1.113	0.383-3.235	0.845	0.607
hormone and chemo	16	0.412	0.129-1.316	0.134	0.022	0.637	0.173-2.343	0.497	0.064	0.634	0.204-1.973	0.432	0.049	1.352	0.441-4.148	0.598	0.269
hormone and radiation	10	0.358	0.069-1.862	0.222	0.180	0.495	0.096-2.558	0.401	0.568	0.250	0.029-2.180	0.209	0.185	0.827	0.192-3.561	0.798	0.597
hormone, chemo, radiation	21	0.598	0.169-2.112	0.424	0.763	0.604	0.218-1.676	0.333	0.801	0.867	0.278-2.710	0.806	0.375	0.894	0.310-2.580	0.836	0.810
chemo no (all subgroups)	30	0.711	0.320-1.580	0.403	0.025	0.794	0.366-1.722	0.560	0.233	0.903	0.391-2.084	0.811	0.134	0.978	0.425-2.254	0.959	0.612
chemo yes (all subgroups)	89	0.582	0.371-0.913	0.019	0.001	0.873	0.552-1.383	0.564	0.520	0.694	0.439-1.098	0.119	0.003	1.181	0.754-1.848	0.468	0.327
chemo (CMF)	55	0.524	0.290- 0.943	0.031	0.008	0.727	0.403-1.314	0.291	0.693	0.706	0.391-1.276	0.249	0.013	1.113	0.626-1.979	0.715	0.337
chemo (AC/CMF)	34	0.688	0.338-1.400	0.302	0.144	1.252	0.596-2.632	0.553	0.543	0.681	0.329-1.410	0.301	0.121	1.280	0.608-2.694	0.515	0.727
chemo alone	13	0.418	0.111-1.574	0.197	0.763	1.207	0.367-3.971	0.757	0.637	0.711	0.205-2.468	0.592	0.047	1.200	0.362-3.980	0.766	0.560
chemo and radiation	39	0.546	0.285-1.047	0.069	0.027	1.343	0.686-2.629	0.389	0.449	0.623	0.320-1.213	0.164	0.444	1.215	0.641-2.304	0.551	0.950
radiation no (all subgroups)	47	0.647	0.333-1.259	0.200	0.024	0.973	0.519-1.824	0.933	0.203	0.981	0.527-1.826	0.951	0.105	1.400	0.746-2.627	0.294	0.404
radiation yes (all subgroups)	72	0.626	0.376-1.044	0.073	0.002	0.774	0.466-1.285	0.321	0.489	0.675	0.394-1.157	0.153	0.036	1.086	0.659-1.791	0.745	0.832

Cox hazard ratios. The immunohistochemistry results for osteopontin-c and exon 4 were categorized into high staining (path scores 2 and 3) or low staining (path scores 0 and 1). Significant p-values are underlined, and confidence intervals that do not contain 1.0 are shown in bold. The last column displays the p-value for the supremum test, which assesses the proportionality assumption. p-values in italics are significant and indicate low confidence in the proportionality