. 2016 Jul 11;17:80. doi: 10.1186/s12931-016-0397-5

Table 2.

Results from univariate and multivariable analyses assessing the relationship between independent variables and 90-day hospital mortality

Independent variables	Hospital mortality^a
	Univariate analysis		Multivariable analysis^b
	HR (95 % CI)	P-value	HR (95 % CI)	P-value
Baseline variables
Male	1.37 (0.97-1.92)	0.074	1.52 (1.07-2.17)	0.021
APACHE II score^c	1.25 (1.13-1.38)	<0.001	1.23 (1.10-1.37)	<0.001
History of malignancy	1.84 (0.99-3.41)	0.053	1.61 (0.82-3.15)	0.16
End-stage renal disease	1.96 (0.79-4.88)	0.15	1.12 (0.38-3.25)	0.84
Chronic respiratory disease	1.40 (0.97-2.03)	0.073	1.36 (0.91-2.02)	0.14
Chronic heart failure	2.71 (1.53-4.79)	0.001	2.90 (1.57-5.37)	0.001
History of venous thromboembolism	0.50 (0.19-1.37)	0.18	0.64 (0.23-1.75)	0.38
Immunocompromise	1.40 (0.93-2.12)	0.12	1.33 (0.84-2.12)	0.23
BMI^c	0.99 (0.89-1.10)	0.82	-^d	-^d
Medical admission	2.45 (0.61-9.90)	0.22	-^d	-^d
Chronic hepatic failure	0.65 (0.091-4.64)	0.67	-^d	-^d
Daily intervention variables
Inotropes/vasopressors	1.59 (1.15-2.19)	0.005	1.24 (0.88-1.75	0.22
Dialysis	2.84 (1.52-5.30)	0.001	2.71 (1.30-5.65)	0.008
Red blood cell transfusion	1.64 (0.93-2.91)	0.090	1.22 (0.67-2.21)	0.51
Central venous catheterization	1.75 (1.04-2.94)	0.037	1.67 (0.99-2.80)	0.056
Acetylsalicylic acid or clopidogrel	1.44 (1.03-2.01)	0.034	1.28 (0.90-1.81)	0.17
Mechanical ventilation	1.34 (0.68-2.63)	0.40	-^d	-^d
Statins	1.27 (0.84-1.92)	0.26	-^d	-^d
Stress ulcer prophylaxis	1.43 (0.79-2.59)	0.23	-^d	-^d
Erythropoietin-stimulating agents	2.29 (0.57-9.30)	0.25	-^d	-^d
Activated protein C	1.64 (0.41-6.67)	0.49	-^d	-^d

HR hazard ratio, CI confidence interval, BMI body mass index, APACHE Acute Physiology and Chronic Health Evaluation

^aThere were 143 deaths for 90-day hospital mortality, ^bNo multicollinearity detected, ^cResults for 5-point increase, ^dNot included in the multivariable analysis