Table 3.

Results from univariate and multivariable analyses investigating the relationship between independent variables and 90-day ICU mortality

Independent variables	ICU mortalitya
	Univariate analysis		Multivariable analysisb
	HR (95 % CI)	P-value	HR (95 % CI)	P-value
Baseline variables
Male	1.52 (1.01-2.22)	0.042	1.41 (0.95-2.08)	0.096
APACHE II scorec	1.20 (1.07-1.35)	0.002	1.22 (1.07-1.37)	0.002
Chronic respiratory disease	1.47 (0.97-2.23)	0.071	1.27 (0.81-1.97)	0.30
Chronic heart failure	2.48 (1.33-4.64)	0.004	2.58 (1.34-4.97)	0.004
History of venous thromboembolism	0.28 (0.068-1.16)	0.078	0.46 (0.11-1.91)	0.29
Immunocompromise	1.45 (0.91-2.33)	0.11	1.54 (0.94-2.52)	0.084
BMIc	0.97 (0.85-1.10)	0.61	-d	-d
History of malignancy	1.29 (0.57-2.94)	0.54	-d	-d
Medical admission	1.24 (0.31-5.04)	0.76	-d	-d
End-stage renal disease	1.49 (0.50-4.40)	0.47	-d	-d
Chronic hepatic failure	1.21 (0.17-8.67)	0.85	-d	-d
Daily intervention variables
Inotropes/vasopressors	1.35 (0.92-1.98)	0.12	1.29 (0.88-1.92)	0.19
Dialysis	2.06 (1.04-4.09)	0.039	1.64 (0.77-3.52)	0.20
Red blood cell transfusion	1.60 (0.83-3.09)	0.16	1.30 (0.63-2.70)	0.48
Central venous catheterization	1.75 (0.93-3.27)	0.081	1.63 (0.92-2.87)	0.090
Erythropoietin-stimulating agents	2.66 (0.65-10.85)	0.17	1.15 (0.23-5.79)	0.86
Mechanical ventilation	1.05 (0.46-2.40)	0.91	-d	-d
Acetylsalicylic acid or clopidogrel	1.22 (0.82-1.81)	0.32	-d	-d
Statins	0.93 (0.56-1.55)	0.78	-d	-d
Stress ulcer prophylaxis	1.33 (0.64-2.74)	0.44	-d	-d
Activated protein C	0.86 (0.21-3.50)	0.84	-d	-d

HR hazard ratio, CI confidence interval, BMI body mass index, APACHE Acute Physiology and Chronic Health Evaluation

^aThere were 108 deaths for 90-day ICU mortality

^bNo multicollinearity detected

^cResults for 5-point increase

^dNot included in the multivariable analysis