Table 4.
Sensitivity analysis results from multivariable analyses evaluating the relationship between independent variables and 30-day hospital and ICU mortality
| Independent variables | Hospital mortalitya | ICU mortalityb | ||
|---|---|---|---|---|
| HR (95 % CI) | P-value | HR (95 % CI) | P-value | |
| Baseline variables | ||||
| Male | 1.39 (0.96-1.96) | 0.090 | 1.30 (0.85-2.04) | 0.22 |
| APACHE II scorec | 1.29 (1.14-1.47) | <0.001 | 1.20 (1.06-1.37) | 0.004 |
| History of malignancy | 1.46 (0.70-3.03) | 0.31 | -d | -d |
| End-stage renal disease | 1.13 (0.38-3.39) | 0.82 | -d | -d |
| Chronic respiratory disease | 1.49 (0.98-2.27) | 0.063 | 1.45 (0.92-2.28) | 0.11 |
| Chronic heart failure | 2.25 (1.16-4.34) | 0.017 | 2.57 (1.32-5.02) | 0.006 |
| History of venous thromboembolism | 0.76 (0.28-2.09) | 0.59 | 0.52 (0.13-2.12) | 0.36 |
| Immunocompromise | 1.48 (0.91-2.41) | 0.12 | 1.43 (0.85-2.39) | 0.17 |
| Daily intervention variables | ||||
| Inotropes/vasopressors | 1.21 (0.84-1.75) | 0.31 | 1.07 (0.71-1.62) | 0.75 |
| Dialysis | 2.29 (1.03-5.11) | 0.042 | 1.33 (0.59-2.98) | 0.49 |
| Red blood cell transfusion | 1.20 (0.62-2.30) | 0.59 | 1.38 (0.67-2.84) | 0.39 |
| Central venous catheterization | 1.50 (0.86-2.63) | 0.15 | 1.12 (0.62-2.01) | 0.72 |
| Acetylsalicylic acid or clopidogrel | 1.36 (0.93-2.00) | 0.11 | -d | -d |
| Erythropoietin-stimulating agents | -e | -e | 1.39 c0.32-6.04) | 0.66 |
HR hazard ratio, CI confidence interval, BMI body mass index, APACHE Acute Physiology and Chronic Health Evaluation
aThere were 122 deaths for 30-day hospital mortality; No multicollinearity detected
bThere were 97 deaths for 30-day hospital mortality; No multicollinearity detected
cResults for 5-point increase
dNot included in the multivariable analysis for ICU mortality
eNot included in the multivariable analysis for hospital mortality