CLP‐1 +/− mice hearts subjected to ischemia/reperfusion show a cardioprotective phenotype. (A) aortic flow, (B) coronary flow, (C) Heart rate, (D) Developed pressure and (E) first derivative of developed pressure, respectively reveal that the haemodynamic parameters in CLP‐1 +/− mice hearts are similar to those of preconditioned wild‐type heart during ischemia/reperfusion. Ischemia, reperfusion and preconditioning were done as described in ‘Materials and Methods’. Results are shown as mean ± S.E.M. of six mice per group. *P < 0.05 versus control, **P < 0.01 versus control.