Figure 4.

Administration of N/OFQ following sensitization and challenge with OVA regulates release of inflammatory mediators in vivo. (A) IL‐4, (B) IL‐5, (C) IL‐12, (D) IL‐13, (E) IL‐10 and (F) IL‐17 cytokine levels in mouse BAL fluid obtained from different treatment groups, n = 5–9 mice. Data are expressed as pg·mL⁻¹ (mean ± SEM). (G) Measurement of OVA‐specific IgE in BAL fluid (n = 5 mice) and (H) in plasma (n = 10–12 mice). Data are expressed as ng·mL⁻¹ (mean ± SEM). (I) Measurement of OVA‐specific IgG levels in mouse BAL fluid and (J) in mouse plasma. Data are expressed as U·mL⁻¹ (mean ± SEM). Statistical comparisons by one‐way anova followed by appropriate post hoc tests where relevant. *P <0.05.