Skip to main content
. 2016 Mar 6;173(8):1286–1301. doi: 10.1111/bph.13416

Figure 7.

Figure 7

N/OFQ‐NOP activation promotes wound repair of human airway structural cells and inhibits recruitment of mucin‐labelled cells in vivo. (A) Wound repair of undifferentiated healthy (n = 3 HBEC samples from 3 independent donors) and (B) asthmatic HBEC (n = 5 HBEC samples from 5 independent donors). (C) Wound repair of non‐asthmatic (n = 5 HASM cell samples from 5 independent donors) and (D) asthmatic HASMs (n = 5 HASM cell samples from 5 independent donors). (E) Mucin‐labelled cells (green) in airway epithelium following administration of N/OFQ post‐OVA sensitization (n = airway tissue from 7 mice), scale bars 20 μm. (F) Mucin‐labelled cells (green) in airway epithelium following administration of N/OFQ prior to OVA sensitization (n = airway tissue from 4 mice). Data are expressed as mean ± SEM. Comparisons by one‐way anova followed by appropriate post hoc tests where relevant. *P <0.05; # P <0.05. In panels (C and D), there was a significant time (P <0.05) and dose‐dependent closure of HASM wound (P <0.05; repeated measures by two‐way anova).