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. 1972 Jun;35(3):403–413. doi: 10.1136/jnnp.35.3.403

Some aspects of the pathology and pathogenesis of the myelopathy caused by disc protrusions in the dog

I R Griffiths 1
PMCID: PMC494083  PMID: 5035314

Abstract

The pathological changes in 23 cord lesions caused by disc protrusion are described. It is suggested that three broad classifications of damage can be found: (1) compressive change; (2) malacia; and (3) diffuse demyelination. The distribution of damage, within the segment, was different in each type of change as were the glial and vascular reactions. It is suggested that vascular factors play a major part in the pathology of the malacic and demyelinating lesions and may be of secondary importance in compressive lesions.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. ADAMS H. D., VAN GEERTRUYDEN H. H. Neurologic complications of aortic surgery. Ann Surg. 1956 Oct;144(4):574–610. doi: 10.1097/00000658-195610000-00005. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. BARRON K. D., HIRANO A., ARAKI S., TERRY R. D. Experiences with metastatic neoplasms involving the spinal cord. Neurology. 1959 Feb;9(2):91–106. doi: 10.1212/wnl.9.2.91. [DOI] [PubMed] [Google Scholar]
  3. Breig A., Turnbull I., Hassler O. Effects of mechanical stresses on the spinal cord in cervical spondylosis. A study on fresh cadaver material. J Neurosurg. 1966 Jul;25(1):45–56. doi: 10.3171/jns.1966.25.1.0045. [DOI] [PubMed] [Google Scholar]
  4. Garland H., Greenberg J., Harriman D. G. Infarction of the spinal cord. Brain. 1966 Dec;89(4):645–662. doi: 10.1093/brain/89.4.645. [DOI] [PubMed] [Google Scholar]
  5. Gillilan L. A. Veins of the spinal cord. Anatomic details; suggested clinical applications. Neurology. 1970 Sep;20(9):860–868. doi: 10.1212/wnl.20.9.860. [DOI] [PubMed] [Google Scholar]
  6. HOERLEIN B. F. Intervertebral disc protrusions in the dog. I. Incidence and pathological lesions. Am J Vet Res. 1953 Apr;14(51):260–269. [PubMed] [Google Scholar]
  7. Hughes J. T., Brownell B. Spinal cord ischemia due to arteriosclerosis. Arch Neurol. 1966 Aug;15(2):189–202. doi: 10.1001/archneur.1966.00470140079011. [DOI] [PubMed] [Google Scholar]
  8. MAIR W. G. P., DRUCKMAN R. The pathology of spinal cord lesions and their relation to the clinical features in protrusion of cervical intervertebral discs; a report of four cases. Brain. 1953 Mar;76(1):70–91. doi: 10.1093/brain/76.1.70. [DOI] [PubMed] [Google Scholar]
  9. PAYNE E. E., SPILLANE J. D. The cervical spine; an anatomico-pathological study of 70 specimens (using a special technique) with particular reference to the problem of cervical spondylosis. Brain. 1957 Dec;80(4):571–596. doi: 10.1093/brain/80.4.571. [DOI] [PubMed] [Google Scholar]
  10. Palmer A. C. Clinical and pathological aspects of cervical disc protrusion and primary tumours of the cervical spinal cord in the dog. J Small Anim Pract. 1970 Jan;11(1):63–67. doi: 10.1111/j.1748-5827.1970.tb07040.x. [DOI] [PubMed] [Google Scholar]
  11. ROMANUL F. C., ABRAMOWICZ A. CHANGES IN BRAIN AND PIAL VESSELS IN ARTERIAL BORDER ZONES; A STUDY OF 13 CASES. Arch Neurol. 1964 Jul;11:40–65. doi: 10.1001/archneur.1964.00460190044004. [DOI] [PubMed] [Google Scholar]
  12. SCHNEIDER R. C., CROSBY E. C. Vascular insufficiency of brain stem and spinal cord in spinal trauma. Neurology. 1959 Oct;9:643–656. doi: 10.1212/wnl.9.10.643. [DOI] [PubMed] [Google Scholar]
  13. STOLTMANN H. F., BLACKWOOD W. THE ROLE OF THE LIGAMENTA FLAVA IN THE PATHOGENESIS OF MYELOPATHY IN CERVICAL SPONDYLOSIS. Brain. 1964 Mar;87:45–50. doi: 10.1093/brain/87.1.45. [DOI] [PubMed] [Google Scholar]
  14. TAYLOR A. R. VASCULAR FACTORS IN THE MYELOPATHY ASSOCIATED WITH CERVICAL SPONDYLOSIS. Neurology. 1964 Jan;14:62–68. doi: 10.1212/wnl.14.1.62. [DOI] [PubMed] [Google Scholar]
  15. THOMPSON G. B. Dissecting aortic aneurysm with infarction of the spinal cord. Brain. 1956 Mar;79(1):111–118. doi: 10.1093/brain/79.1.111. [DOI] [PubMed] [Google Scholar]
  16. WILKINSON M. The morbid anatomy of cervical spondylosis and myelopathy. Brain. 1960 Dec;83:589–617. doi: 10.1093/brain/83.4.589. [DOI] [PubMed] [Google Scholar]
  17. WOODARD J. S., FREEMAN L. W. Ischemia of the spinal cord; an experimental study. J Neurosurg. 1956 Jan;13(1):63–72. doi: 10.3171/jns.1956.13.1.0063. [DOI] [PubMed] [Google Scholar]
  18. WOOLF A. L. Experimentally produced cerebral venous obstruction. J Pathol Bacteriol. 1954 Jan;67(1):1–16. [PubMed] [Google Scholar]
  19. Wright F., Palmer A. C. Morphological changes caused by pressure on the spinal cord. Pathol Vet. 1969;6(4):355–368. doi: 10.1177/030098586900600405. [DOI] [PubMed] [Google Scholar]

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