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. 2016 Jul 11;8:74. doi: 10.1186/s13073-016-0328-6

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© The Author(s). 2016

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 2 — Chromatin dynamics and gene expression profiles from nuclear receptor activation. a The number of differentially regulated genes (up- and down-regulated) after 24 and 48 h of drug treatment (adjusted p < 0.01 and fold change cutoff ±2). b Gene Ontology connectivity map for GW3965 at 24 h for up-regulated (red) and down-regulated (red) pathways. c Gene Ontology connectivity map for GW3965 at 48 h for up-regulated (red) and down-regulated (red) pathways. d The number of H3K27ac sites gained (red) and lost (blue) after 24 and 48 h of GW3965 and rosiglitazone drug treatment