Table 4.
Hazard ratios (HRs) of PCa recurrent free survival and PCa-specific mortality after radical prostatectomy by ERβ2 staining in tumor epithelium quantified by image analysis (per tertile increment)
| RFS | PCSM | |||
|---|---|---|---|---|
| HR (95 % CI) | p-value | HR (95 % CI) | p-value | |
| Cytoplasmic Digital IHC (CytoOD*%PosCyto) | ||||
| Univariate | 1.07 (0.85, 1.34) | 0.561 | 2.16 (1.02, 4.57) | 0.045 |
| Multivariate a | 1.06 (0.84, 1.33) | 0.624 | 1.98 (0.93, 4.21) | 0.075 |
| Nuclear Digital IHC (NucOD*%PosNuc) | ||||
| Univariate | 1.11 (0.89, 1.40) | 0.352 | 2.67 (1.20, 5.96) | 0.016 |
| Multivariate a | 1.00 (0.79, 1.27) | 0.999 | 2.32 (0.99, 5.41) | 0.052 |
| Total Malignant Epithelial Area Digital IHC (OD*%Pos) | ||||
| Univariate | 1.25 (0.99, 1.57) | 0.057 | 5.10 (1.70, 15.34) | 0.004 |
| Multivariate a | 1.19 (0.94, 1.51) | 0.150 | 4.08 (1.37, 12.15) | 0.012 |
a Adjusted for age at diagnosis (years), Gleason score (≤6, 7[3 + 4], 7[4 + 3], and ≥8), pathological stage (local: pT2, N0/NX, M0; regional: pT3/pT4 or N1-3, M0), and diagnostic PSA level (1 unit increase)