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. 2016 Jul 11;17:488. doi: 10.1186/s12864-016-2809-9

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© The Author(s). 2016

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 3 — microRNA-target mRNA sub-network. The mapping was constituted by 43 down-regulated target mRNAs and 21 up-regulated miRNAs. The green circles represent down-regulated target mRNAs, and the red triangles denote up-regulated miRNAs. The lines stand for coherent miRNAs-target mRNAs interaction pairs. A single miRNA can target multiple proteins, while a single protein can be targeted by several miRNAs. Multiple miRNAs can cooperatively repress a range of targets