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. 2016 Apr 14;23(7):592–596. doi: 10.1038/gt.2016.32

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Copyright © 2016 Macmillan Publishers Limited

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Effects on human complement activation. Human sera was incubated with Ad (5 × 10¹⁰ vp ml⁻¹) in the presence or absence of 40 μg ml⁻¹ Xbp for 90 min at 37 °C. (a) Human sera with high pre-existing neutralising IgG titres (high NAbs) and sera samples with low IgG titres which exhibited a dependence on FX for protection (low NAbs Group A), (b) FX-depleted human plasma (Quadratech Diagnostics, UK) and (c) C1q depleted human sera were used. C3a-desArg levels were quantified by ELISA. Graphs show transduction as a percentage of serum+phosphate-buffered saline (PBS). *P<0.05 vs matched PBS or Ad5.