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. Author manuscript; available in PMC: 2017 Aug 15.
Published in final edited form as: J Neuroimmunol. 2016 Apr 30;297:1–8. doi: 10.1016/j.jneuroim.2016.04.015

Table 2.

Statistical significance (p values) of T helper-associated cytokines in MS versus control as well as Remission versus Relapse (R vs R)

Mean Median Std Dev Minimum Maximum *p
value
Cytoki
ne		 Ctl Remi
ssion		 Rela
pse		 Ctl Remi
ssion		 Rela
pse		 Ctl Remi
ssion		 Rela
pse		 Ctl Remi
ssion		 Rela
pse		 Ctl Remi
ssion		 Rela
pse		 Remi
ssion		 Rela
pse		 R
vs
R
Th1-associated cytokines IFNg 0.899 16.830 5.539 0.00 0.00 0.00 2.052 62.064 10.428 0. 00 0.00 0.00 5.97 313.31 31.21 0.22 0.18 0.81
IFNg IL-12p70 3.846 22.559 9.159 3.18 6.02 8.03 2.466 75.233 7.466 0.00 0.00 0.00 9.63 389.43 29.21 0.12 0.02 0.58
TNFb 0.000 0.045 0.038 0.00 0.00 0.00 0.000 0.104 0.076 0.00 0.00 0.00 0.00 0.36 0.25 0.08 0.05 0.82
IL-2 0.000 13.125 8.692 0.00 0.00 0.00 0.000 35.776 15.907 0.00 0.00 0.00 0.00 165.80 55.45 0.09 0.1 0.88
Th2-associated cytokines IL-4 0.002 0.033 0.056 0.00 0.00 0.00 0.006 0.102 0.096 0.00 0.00 0.00 0.02 0.50 0.29 0.39 0.12 0.22
IL-33 0.000 35.352 27.701 0.00 3.78 9.12 0.000 88.523 52.371 0.00 0.00 0.00 0.00 388.38 165.60 0.06 0.01 0.49
IL-5 0.132 8.523 1.989 0.00 0.37 0.61 0.381 20.406 4.369 0.00 0.00 0.00 1.27 80.53 16.45 0.04 0.04 0.73
IL-10 0.224 3.846 9.379 0.00 1.36 4.07 0.443 7.900 10.956 0.00 0.00 0.00 1.36 39.35 31.86 0.01 0.004 0.06
IL-13 13.933 35.379 36.059 13.87 29.01 32.39 14.649 39.575 30.234 0.00 0.00 0.00 43.85 154.51 93.57 0.1 0.04 0.59
IL-25/IL-17E 0.017 0.388 0.324 0.00 0.04 0.10 0.025 0.990 0.621 0.00 0.00 0.00 0.06 4.48 2.10 0.1 0.01 0.45
Th17- associated cytokines IL_6 1.711 10.817 8.930 0.00 0.00 0.00 5.674 32.219 17.254 0.00 0.00 0.00 18.82 158.42 47.73 0.11 0.22 0.78
IL-1β 1.127 3.237 4.410 0.00 0.00 0.00 3.739 8.042 7.818 0.00 0.00 0.00 12.40 35.69 25.35 0.15 0.15 0.76
IL-23 0.073 1.600 0.871 0.00 0.18 0.24 0.107 4.309 1.593 0.00 0.00 0.00 0.30 18.31 4.92 0.05 0.005 0.44
IL-17A 0.374 14.068 6.851 0.00 0.00 3.23 0.738 56.682 11.461 0.00 0.00 0.00 2.26 289.55 42.02 0.35 0.02 0.09
IL-17F 0.012 0.036 0.034 0.01 0.02 0.03 0.006 0.056 0.028 0.00 0.00 0.01 0.02 0.28 0.10 0.07 0.006 0.46
IL-21 5.885 18.304 18.219 4.70 13.59 14.43 3.983 22.093 12.998 0.00 0.00 4.23 14.45 111.44 51.30 0.02 0.001 0.55
IL-22 0.000 0.090 0.073 0.00 0.00 0.00 0.000 0.237 0.179 0.00 0.00 0.00 0.00 0.89 0.56 0.27 0.1 0.58
Cytokines associated with multiple T helper cells TNFa 12. 145 19.554 20.434 10. 98 15.28 17.16 6.895 18.602 13.241 0. 00 0.00 2.32 23. 16 96.58 58.94 0.1 0.03 0.38
GM- CSF 0.000 0.097 0.000 0.00 0.00 0.00 0.000 0.366 0.000 0. 00 0.00 0.00 0.00 1.80 0.00 0.78 0.91 0.20
CCL20/ MIP3a 11. 883 27.122 26.546 11. 19 20.46 24.86 6.075 21.577 9.926 2. 99 0.00 10.52 20. 85 104.90 44.78 0.004 0.0003 0.33
IL-9 0.000 7.895 6.152 0.00 0.00 0.00 0.000 22.648 9.131 0.00 0.00 0.00 0.00 112.26 22.67 0.04 0.1 0.92
IL-15 0.228 7.713 9.675 0.00 0.00 1.52 0.757 20.265 14.839 0.00 0.00 0.00 2.51 91.59 46.98 0.11 0.01 0.20
IL-27 0.189 1.109 1.066 0.13 0.59 0.66 0.185 1.530 0.948 0.00 0.21 0.36 0.52 6.98 3.46 0.0002 <0.0001 0.32
IL-28A 0.018 0.185 0.153 0.00 0.11 0.08 0.034 0.281 0.228 0.00 0.00 0.00 0.10 1.05 0.86 0.006 0.01 0.82
IL-31 0.005 0.184 0.126 0.00 0.02 0.04 0.008 0.537 0.240 0.00 0.00 0.00 0.02 2.67 0.75 0.01 0.002 0.60