Table 3.

Linear regression analyses: duration of disease (years) and cytokine levels (pg/mL).

Cytokine	MS Remission		MS Relapse
Th1-associated cytokines
	R²	P value	R²	P value
IFNγ	0.002	0.82	0.001	0.89
IL-12p70	0.000	0.98	0.082	0.32
TNFβ	*0.140*	*0.05*	0.000	0.95
IL-2	0.057	0.24	0.015	0.67
Th2-associated cytokines
IL-4	*0.274*	*0.006*	0.007	0.76
IL-33	*0.211*	*0.02*	0.002	0.87
IL-5	0.015	0.55	0.007	0.78
IL-10	*0.239*	*0.01*	0.044	0.47
IL-13	0.102	0.11	0.014	0.69
IL-25/IL-17E	*0.238*	*0.01*	0.003	0.84
Th17-associated cytokines
IL-6	0.034	0.37	0.001	0.90
IL-1β	*0.244*	*0.01*	0.013	0.70
IL-23	*0.202*	*0.02*	0.006	0.79
IL-17A	0.000	0.94	0.009	0.74
IL-17F	*0.302*	*0.003*	0.012	0.70
IL-21	0.003	0.79	0.078	0.33
IL-22	*0.177*	*0.03*	0.000	0.99
Cytokines associated with multiple T helper cells
TNFα	0.025	0.44	0.012	0.71
GM-CSF	0.000	0.90	0.002	0.43
CCL20/MIP3α	0.018	0.50	0.003	0.84
IL-9	0.015	0.55	0.023	0.60
IL-15	*0.287*	*0.004*	0.004	0.82
IL-27	*0.188*	*0.03*	0.001	0.91
IL-28A	0.083	0.15	0.000	0.99
IL-31	*0.275*	*0.006*	0.005	0.81