Table 5.
Author | Crude incidence rate per 1000 person-years in HIV/HCV-coinfection (95% CI) [fracture type] | Predictors of fractures from multivariate analysis [population of predictor analysis] |
---|---|---|
Hansen et al. [40] | 39.15 (34.54–44.39) [all fractures] | NAa |
Yin et al. [34] | 26.78 (20.40–35.14)e [all fractures] | HCV-infection, older age, white race, high serum creatinine [HIV-infected and uninfected] |
Young et al. [21] | 62.27 (47.33–81.94)b [all fractures] | HCV-infectionc, older agec, BMI <18.5 kg/m2c, substance abuse, nadir CD4+ cell count <200 cells/μl, diabetes [all HIV-infected] |
Collin et al. [35] | 7.18 (4.08–12.64)e [high-grade fractures] | HCV-coinfection, excessive alcohol drinking [all HIV-infected] |
Lo Re III et al. [6] | 3.75 (3.48–4.06) [only hip fractures] | Older age, hepatic decompensationd [all patients, HIV-infected and uninfected] |
Maalouf et al. [27] | 2.57 (2.33–2.84) [fragility fractures] | HCV-coinfection, older age, white race, tobacco use, low BMI (<20 kg/m2), cirrhosis, APRI score [all HIV-infected] |
ADI, AIDS-defining illness; APRI, aspartate aminotransferase-to-platelet ratio index.
Predictors not reported because all HCV-infected individuals were excluded from final analysis.
Extrapolated from data on Table 4 of Young et al. [21], Risk Factors for Bone Fracture Among 5054 HOPS Patients followed during the contemporary. HAART Era, 2002–2008.
Remained significant when analysis was limited to only fragility fractures.
Hepatic decompensation was unique to HCV-monoinfected group analysis.
Calculated from unpublished data obtained from authors.