Table 3.
Diagnostic Performance of Optical Diagnosis of Diminutive Colorectal Polyps Using Narrow-Band Imaging
| Overall | High confidence | Low confidence | |
|---|---|---|---|
| All, n | 2876a | 2178 | 694 |
| Accuracy | 76.7 (75.2–78.3) | 84.8 (82.1–87.5) | 60.2 (55.4–65.1) |
| Sensitivity | 95.2 (92.6–97.8) | 97.6 (95.3–99.9) | 74.6 (65.9–83.4) |
| Specificity | 61.6 (55.8–67.4) | 68.9 (60.5–77.2) | 50.6 (45.6–55.7) |
| Area under ROC | 0.78 (0.77–0.80) | 0.84 (0.82–0.85) | 0.62 (0.58–0.66) |
| PPV | 77.9 (74.2–81.6) | 83.1 (79.1–87.2) | 55.3 (45.6–64.9) |
| NPV | 94.2 (90.4–98.0) | 98.3 (95.7–100.0) | 80.8 (67.9–93.7) |
| Proximal to rectosigmoid, n | 1818 | 1360 | 456 |
| Accuracy | 78.8 (75.5–82.0) | 84.7 (80.7–88.6) | 61.3 (54.3–68.4) |
| Sensitivity | 91.0 (88.3–94.0) | 96.2 (94.1–98.4) | 73.7 (65.8–81.5) |
| Specificity | 36.9 (27.7–46.1) | 34.9 (22.1–47.7) | 44.4 (37.3–51.1) |
| Area under ROC | 0.72 (0.70–0.75) | 0.79 (0.76–0.81) | 0.59 (0.54–0.65) |
| PPV | 83.5 (79.4–87.6) | 85.2 (80.9–89.5) | 72.9 (60.2–85.6) |
| NPV | 65.6 (59.2–71.9) | 77.1 (67.9–86.2) | 54.2 (44.1–64.3) |
| Rectosigmoid, n | 1058 | 818 | 238 |
| Accuracy | 80.9 (76.7–85.1) | 88.1 (83.2–92.9) | 60.5 (52.5–68.5) |
| Sensitivity | 88.4 (84.8–92.0) | 90.9 (87.4–94.4) | 73.9 (61.2–86.6) |
| Specificity | 78.3 (71.8–84.9) | 88.6 (81.0–96.1) | 57.8 (46.9–68.8) |
| Area under ROC | 0.75 (0.72–0.79) | 0.80 (0.77–0.84) | 0.60 (0.50–0.69) |
| PPV | 56.8 (51.1–62.4) | 65.7 (60.9–70.6) | 29.1 (20.8–37.3) |
| NPV | 93.7 (91.8–95.7) | 94.7 (92.6–96.8) | 90.1 (84.8–95.4) |
NOTE. Values are % (95% CI) unless otherwise noted.
NPV, negative predictive value; PPV, positive predictive value; ROC, receiver operating characteristics.
a
Polyps were excluded from analysis if histology was missing, other, or unable to retrieve; and if confidence designation was missing.