Table 1.
Clinicopathological characteristics and PIK3CA H1047R mutation status in 86 CRC cases
| Category | Total (n) | Direct sequencing | PCR-RFLP | ||
|---|---|---|---|---|---|
| Mutation (%) | P-value | Mutation (%) | P-value | ||
| Number of patients | 86 | 8 (9.3) | 14 (16.3) | ||
| Age (years) | 0.145 | 0.018* | |||
| >60 | 49 | 7 (14.3) | 12 (24.5) | ||
| ≤60 | 37 | 1 (2.7) | 2 (5.4) | ||
| Gender | 0.275 | 0.498 | |||
| Male | 53 | 3 (5.7) | 7 (13.2) | ||
| Female | 33 | 5 (15.2) | 7 (21.2) | ||
| Tumor size | 0.924 | 0.702 | |||
| >5 cm | 47 | 5 (10.6) | 7 (14.9) | ||
| ≤5 cm | 39 | 3 (7.7) | 7 (17.9) | ||
| Tumor location | 0.428 | 0.564 | |||
| Colon | 37 | 5 (13.5) | 7 (18.9) | ||
| Rectum | 49 | 3 (6.1) | 7 (14.3) | ||
| Tumor differentiation | 0.001* | < 0.0001* | |||
| Well or Moderate | 67 | 2 (3.0) | 4 (6.0) | ||
| Poor | 19 | 6 (31.6) | 10 (52.6) | ||
| Dukes’ stage | 1.000 | 1.000 | |||
| A + B | 60 | 6 (10) | 10 (16.7) | ||
| C + D | 26 | 2 (7.7) | 4 (15.4) | ||
| Lymph node metastasis | 0.603 | 0.708 | |||
| + | 34 | 2 (5.9) | 4 (11.8) | ||
| − | 69 | 6 (8.7) | 10 (14.5) | ||
*Statistically significant (p < 0.05)