Table 3.
Family | Protease inhibitor | Targeted proteases | Source | Possible sites of action |
---|---|---|---|---|
Serpins | Serpin A1 | Trypsin/chymase/tryptase/elastase/proteinase-3/cathepsin G/thrombin/kallikreins | Systemic | M, P |
Serpin A3 | Chymotrypsin/chymase/cathepsin G | Systemic | M, P | |
Serpin A4 | Kallikreins | Systemic | M, P | |
Serpin E1 | Plasminogen activator | Systemic | M, P | |
Serpin C1 | Thrombin | Systemic | M, P | |
Chelonianin | SLPI | Elastase/cathepsin G/trypsin/chymotrypsin/tryptase/chymase | Local | L, M, P, I |
Elafin | Elastase, proteinase-3 | Local | L, M, P, I | |
TIMPs | TIMP-1 | MMP-1/MMP-2/MMP-3/MMP-4/MMP-6/MMP-19/ADAM-10/ADAM-17 | Systemic and local | M, P |
TIMP-2 | MMP-1, MMP-2, MMP-14 | M, P | ||
TIMP-3 | Membrane-bound MMPs | Local | M, P | |
TIMP-4 | MMP-1/MMP-2/MMP-3/MMP-4/MMP-6/MMP-19 | Systemic | M, P | |
c-IAP2 | Caspase-9 | Local | I |
ADAM, A Disintegrin And Metalloprotease; c-IAP2, cellular inhibitor of apoptosis protein-2; I, intracellular; L, lumen; M, matrix; MMP, matrix metalloproteinases; P, plasma; TIMPs, tissue inhibitors of metalloproteinases; SLPI, secretory leucocyte protease inhibitor.