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. 2015 Sep 15;75(7):1336–1342. doi: 10.1136/annrheumdis-2015-207760

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Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/

This is an Open Access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/

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Smoothed time courses of Clinical Disease Activity Index (CDAI) by tocilizumab (TCZ) treatment. The data represent all 1702 eligible patients with at least one CDAI value totalling 9943 observations. Data were smoothed separately for each TCZ treatment using local quadratic regression. Treatment groups ‘TCZ’, ‘TCZ+ methotrexate (MTX)’, ‘TCZ+MTX_plus’, and ‘TCZ+other’ represent TCZ as monotherapy and in combination with MTX, MTX+other synthetic disease-modifying antirheumatic drugs (sDMARD(s)), and at least one sDMARD other than MTX, respectively. Numbers of patients providing CDAI information beyond 12, 24, 36 and 48 months were 162, 76, 32 and 7 for ‘TCZ’, 427, 262, 133 and 41 for ‘TCZ+MTX’, 80, 41, 21 and 11 for ‘TCZ+MTX_plus’, and 90, 55, 27 and 11 for ‘TCZ+other’, respectively. Of note, all Swedish patients were excluded due to lack of a global physician's assessment of disease in this registry.