Overlay of HLD‐I structures. (A) Overlay of the structures of DccA (purple), DppA (green), DmrA(turquoise), and DhlA(yellow) with its cocrystallized 1,2‐dichloroethane with the backbones shown as ribbon diagrams. (B) Active site residues (Asp123: nucleophile, His278: general base, Asp249: catalytic acid, Trp124 and Trp 163: halide‐stabilizing residues) are shown as stick models. This figure was made using Discovery Studio 4.0.28