Table 2.
Mean baseline BMI and plasma leptin concentrations across genotype groups in the DIRECT population
| SNP | Genotype | N | BMI (kg m–2) | P-value | Plasma leptin, male (mg dl–1) | P-value | Plasma leptin, female (mg dl–1) | P-value |
|---|---|---|---|---|---|---|---|---|
| rs11760956 | GG | 139 | 31.0 ± 3.5 | 0.6343 | 8.9 ± 5.0 | 0.2967 | 28.1 ± 12.9 | 0.4284 |
| AG | 99 | 30.6 ± 3.7 | 9.7 ± 5.6 | 31.8 ± 14.7 | ||||
| AA | 24 | 30.4 ± 3.4 | 10.9 ± 10.6 | 38.2 ± 5.8 | ||||
| rs3828942 | GG | 79 | 31.2 ± 3.8 | 0.4654 | 7.6 ± 2.5 | 0.0172 | 28.1 ± 9.6 | 0.7949 |
| AG | 127 | 30.7 ± 3.5 | 8.9 ± 5.3 | 31.5 ± 15.4 | ||||
| AA | 56 | 30.4 ± 3.6 | 8.2 ± 4.0 | 30.9 ± 12.4 | ||||
| rs4731426 | CC | 87 | 30.8 ± 3.4 | 0.9511 | 8.7 ± 4.3 | 0.0834 | 30.8 ± 14.5 | 0.8641 |
| CG | 116 | 30.7 ± 3.8 | 9.1 ± 5.6 | 30.9 ± 13.5 | ||||
| GG | 59 | 30.9 ± 3.4 | 11.0 ± 2.2 | 27.3 ± 11.2 | ||||
| rs117635178 | TT | 78 | 30.6 ± 3.7 | 0.5728 | 8.4 ± 8.6 | 0.1126 | 27.9 ± 10.8 | 0.8666 |
| CT | 131 | 30.7 ± 3.4 | 9.5 ± 5.2 | 31.2 ± 14.6 | ||||
| CC | 53 | 31.2 ± 4.0 | 1.7 ± 8.5 | 29.8 ± 11.3 | ||||
| rs2071045 | TT | 144 | 30.4 ± 3.3 | 0.0918 | 9.5 ± 6.5 | 0.7644 | 29.4 ± 12.1 | 0.2388 |
| TC | 100 | 31.4 ± 4.0 | 9.3 ± 2.9 | 35.3 ± 16.4 | ||||
| CC | 18 | 30.7 ± 2.9 | 8.2 ± 3.9 | 24.3 ± 7.2 |
Abbreviations: BMI, body mass index; DIRECT, Dietary Intervention Randomized Controlled Trial; SNP, single-nucleotide polymorphism.