Table 3b.
Associations between changes (delta) in biomarkers in the first 6 months of the weight loss dietary intervention and weight change during the weight loss phase (0–6 months) (model 1) and the weight maintenance/regain phase (7–24 months) (model 2); multivariate regression analysisa
Model 1 to predict weight change between 0–6 months | P-value | Model 2 to predict weight change between 7–24 months | P-value | |
---|---|---|---|---|
Leptin, delta 0–6 months | 0.505 | <0.001 | –0.131 | 0.013 |
Adiponectin, delta 0–6 months | –0.301 | 0.023 | 0.111 | 0.356 |
CRP, delta 0–6 months | 0.028 | 0.743 | 0.236 | 0.002 |
TG, delta 0–6 months | 0.006 | 0.132 | 0.003 | 0.465 |
HDL-c, delta 0–6 months | –0.159 | 0.001 | 0.049 | 0.252 |
LDL-c, delta 0–6 months | 0.029 | 0.002 | 0.002 | 0.838 |
Fasting glucose, delta 0–6 months | 0.001 | 1.000 | –0.016 | 0.190 |
Weight change in %, delta 0–6 months | — | — | –0.102 | 0.063 |
Abbreviations: CRP, C-reactive protein; HDL-c, high-density lipoprotein cholesterol; LDL-c, low-density lipoprotein cholesterol; TG, triglyceride.
Adjusted simultaneously to all the variables in the model + adjusted to the age, sex and diet group. The variables are in continuous form except for sex (men vs women) and diet intervention group (1 = low-fat, 2 = Mediterranean, 3 = low-carbohydrate diet); weight change is measured as percent of changes at 6 months as compared with baseline.