. Author manuscript; available in PMC: 2016 Jul 12.

Published in final edited form as: Int J Obes (Lond). 2010 Nov 2;35(6):785–792. doi: 10.1038/ijo.2010.217

Table 4.

Association between LEP genotype and weight regain in months 7–24

SNP	Minor allele	Multvariate association with individual SNPs						Multivariate association
		Basic model ^a		FDR	Full model ^b		FDR	General model ^c	Parsimonious model ^c
		β ^d	P-value		β	P-value		Adjusted r²	Adjusted r²
No SNP								0.1085	0.1085
rs4731426	G	1.085	0.001	0.005	0.872	0.006	0.016
rs117635178	C	0.477	0.152	0.152	0.096	0.776	0.776
rs11760956	A	0.64	0.061	0.076	0.391	0.269	0.336	0.1449	0.1454
rs2071045	C	–0.926	0.016	0.027	–1.026	0.006	0.016
rs3828942	A	–0.889	0.007	0.017	–0.587	0.075	0.126
P-value for addition								0.0297	0.0141

Abbreviations: FDR, false discovery rate; SNP, single-nucleotide polymorphism.

The basic models are adjusted for age, sex and diet group only.

The full models are adjusted for age, sex, diet group and changes in weight, leptin, adiponectin and high-density lipoprotein cholesterol concentrations between 0–6 months.

The general model consists of all five SNPs. The parsimonious model consists of only three SNPs (rs4731426, rs2071045 and rs3828942).

The β value is for each additional copy of the minor allele.