Table 5.
Multivariate models of LEP haplotypes association with weight regain
| rs4731426 | rs117635178 | rs11760956 | rs2071045 | rs3828942 | Haplotype frequency |
Generalized linear model tests
|
Score statistics tests
|
|||
|---|---|---|---|---|---|---|---|---|---|---|
| β | P-value | Hap-Score | P-value | |||||||
| 1 | C | T | G | T | A | 0.2758 | Ref. | — | 0.3135 | 0.7539 |
| 2 | C | T | G | C | A | 0.1096 | –1.0713 | 0.0736 | –2.2448 | 0.0248 |
| 3 | C | C | G | C | G | 0.1204 | –0.8009 | 0.1585 | –1.5839 | 0.1132 |
| 4 | G | C | G | T | G | 0.0541 | 0.4235 | 0.5490 | 0.8022 | 0.4224 |
| 5 | G | T | G | T | G | 0.0961 | 0.9197 | 0.1568 | 1.9164 | 0.0553 |
| 6 | G | C | A | T | G | 0.2582 | 0.3517 | 0.4223 | 1.5868 | 0.1126 |
| — | * | * | * | * | * | 0.0858 | –0.7900 | 0.1892 | — | — |
| P-valuea | 0.0308 | |||||||||
| Simulated P-valuea | 0.0286 | |||||||||
a
The P-values are of asymptotic and simulated global tests.
All models are adjusted for age, sex, diet group and changes in weight, leptin, adiponectin and HDL-c concentrations between 0–6 months. The last row includes all other haplotypes. Asterisks (*) denote any of the two possible nucleotides for the individual SNP.