. Author manuscript; available in PMC: 2016 Jul 12.

Published in final edited form as: Int J Obes (Lond). 2010 Nov 2;35(6):785–792. doi: 10.1038/ijo.2010.217

Table 5.

Multivariate models of LEP haplotypes association with weight regain

	rs4731426	rs117635178	rs11760956	rs2071045	rs3828942	Haplotype frequency	Generalized linear model tests		Score statistics tests
	rs4731426	rs117635178	rs11760956	rs2071045	rs3828942	Haplotype frequency	β	P-value	Hap-Score	P-value
1	C	T	G	T	A	0.2758	Ref.	—	0.3135	0.7539
2	C	T	G	C	A	0.1096	–1.0713	0.0736	–2.2448	0.0248
3	C	C	G	C	G	0.1204	–0.8009	0.1585	–1.5839	0.1132
4	G	C	G	T	G	0.0541	0.4235	0.5490	0.8022	0.4224
5	G	T	G	T	G	0.0961	0.9197	0.1568	1.9164	0.0553
6	G	C	A	T	G	0.2582	0.3517	0.4223	1.5868	0.1126
—	*	*	*	*	*	0.0858	–0.7900	0.1892	—	—
P-value^a									0.0308
Simulated P-value^a									0.0286

The P-values are of asymptotic and simulated global tests.

All models are adjusted for age, sex, diet group and changes in weight, leptin, adiponectin and HDL-c concentrations between 0–6 months. The last row includes all other haplotypes. Asterisks (*) denote any of the two possible nucleotides for the individual SNP.