Table 3. Hazard Ratios for Diabetic and Nondiabetic End-Stage Renal Disease (ESRD) in Adulthood According to Body Mass Index (BMI) Category at Age 17 Yearsa.
Variable | Percentile Subgroup Based on the 2000 CDC Sex-Specific BMI for Age Growth Charts |
Incident Cases of ESRD, No. |
Incidence Rate per 100 000 Person-Years |
Crude HR (95% CI) |
Model 1 Adjusted for Sex, Country of Origin, and Period of Enrollment in the Study, HR (95% CI) |
Model 2 Adjusted for Sex, Country of Origin, Period of Enrollment in the Study, and Systolic Blood Pressure, HR (95% CI)b |
---|---|---|---|---|---|---|
Diabetic ESRD (n = 258) | ||||||
Underweight | <5th | 4 | 0.26 | 0.62 (0.23-1.69) | 0.49 (0.18-1.33) | 0.49 (0.18-1.34) |
Normal weight | 5th to 84th | 134 | 0.51 | 1 [Reference] | 1 [Reference] | 1 [Reference] |
Overweight | 85th to 94th | 63 | 2.72 | 5.39 (3.99-7.27) | 6.01 (4.45-8.12) | 5.96 (4.41-8.06) |
Obese | ≥95th | 57 | 8.21 | 20.58 (15.09-28.06) | 19.81 (14.48-27.10) | 19.37 (14.13-26.55) |
| ||||||
Nondiabetic ESRD (n = 616) | ||||||
Underweight | <5th | 31 | 2.04 | 1.23 (0.86-1.78) | 1.09 (0.76-1.57) | 1.09 (0.76-1.57) |
Normal weight | 5th to 84th | 467 | 1.8 | 1 [Reference] | 1 [Reference] | 1 [Reference] |
Overweight | 85th to 94th | 82 | 3.43 | 1.99 (1.57-2.51) | 2.17 (1.71-2.75) | 2.17 (1.71-2.74) |
Obese | ≥95th | 36 | 5.19 | 3.35 (2.39-4.71) | 3.41 (2.42-4.79) | 3.41 (2.42-4.79) |
Abbreviations: CDC, US Centers for Disease Control and Prevention; HR, hazard ratio.
Normal weight is the reference category for all models. All models yielded P < .001.
Systolic blood pressure above or below the 95th age-specific and sex-specific percentiles.