Table 2. Descriptions of the brain regions extracted from the genotype-by-aMCI interactions that remained statistically significant after correcting for the imaging space and across multiple SNPs per gene.
| Cholesterol metabolism pathway SNP | Allele | Cluster size | Peak MNI coordinates x, y, z | Peak F value | Brain region | Pcorrected (S) < 0.05 | Pcorrected (S,G) < 0.05 |
|---|---|---|---|---|---|---|---|
| ABCA1 (ATP-binding cassette transporter A1) | |||||||
| rs2230806 | AG | 2214 | −21 −102 9 | 12.7 | Middle Occipital Gyrus _L (L.MOG) | * | - |
| 2241 | −15 30 33 | 9.96 | Middle Frontal Gyrus _L (L.MFG) | * | - | ||
| 1539 | 0 −57 0 | 9.95 | Vermis_4_5 (Vermis45) | * | - | ||
| APOE (Apolipoprotein E) | |||||||
| rs7412 | CT | 2079 | −42 27 24 | 19.15 | Inferior Frontal Gyrus_L (L.IFG) | * | - |
| 2025 | −60 −33 −15 | 15.59 | Middle Temporal Gyrus_L (L.MTG) | * | - | ||
| 2403 | 33 −9 15 | 14.79 | Insula_R (R.INS) | * | - | ||
| 1809 | 15 −24 39 | 14.40 | Middle Cingulum Gyrus_R (R. MCG) | * | - | ||
| rs405509 | AC | - | - | - | None | ||
| rs429358 | CT | 2349 | −36 −57 −33 | 81.78 | Cerebellum Posterior Lobe_L (L. CRBL_Po) | * | ** |
| 1485 | 36 15 −36 | 66.04 | Superior Temporal Gyrus_R (R.STG) | * | ** | ||
| 2538 | −3 21 18 | 38.42 | Anterior Cingulate Gyrus_L (L.ACG) | * | - | ||
| 1998 | −12 −45 −3 | 31.11 | Parahippocampal gyrus _L (L.PHG) | * | - | ||
| rs440446 | CG | 2754 | 15 −48 51 | 21.37 | Precuneus_R (R.PCUN) | * | - |
| 2133 | −21 −51 −36 | 21.34 | Cerebellum Anterior Lobe_L (L.CRBL_Ant) | * | - | ||
| 3159 | 21 −57 −39 | 17.91 | Cerebellum Posterior Lobe_R (R. CRBL_Po) | * | - | ||
| 1431 | −57 −66 9 | 15.37 | Middle Temporal Gyrus_L (L.MTG) | * | - | ||
| rs769450 | AG | - | - | - | None | ||
| CH25H (Cholesterol 25-Hydroxylase) | |||||||
| rs4417181 | CT | 1809 | 39 30 15 | 15.37 | Middle Frontal Gyrus_R (R.MFG) | * | - |
| rs7091822 | GT | - | - | - | None | ||
| rs17117126 | AG | - | - | - | None | ||
| CST3 (Cystatin C) | |||||||
| rs2424577 | AG | - | - | - | None | ||
| rs3827143 | AG | None | |||||
| CYP1 (cytochrome P450 1) | |||||||
| rs754203 | CT | 2916 | 30 27 −15 | 17.80 | Inferior Frontal Gyrus_R (R.IFG) | * | - |
| 2079 | 36 −12 −27 | 15.94 | Parahippocampal gyrus_R (R.PHG) | * | - | ||
| rs4900442 | CT | None | |||||
| rs7157609 | AC | 2565 | 30 27 −15 | 15.00 | Inferior Frontal Gyrus_R (R.IFG) | * | - |
| 2106 | 33 −12 −27 | 14.87 | Parahippocampal gyrus_R (R.PHG) | * | - | ||
| IDE (Insulin-degrading enzyme) | |||||||
| rs3758505 | GT | - | - | - | None | ||
| rs4646954 | AG | - | - | - | None | ||
| LDLR (Low-density lipoprotein receptor) | |||||||
| rs688 | CT | None | |||||
| rs5925 | CT | None | |||||
| rs1433099 | AG | 1296 | 3 21 48 | 16.18 | Medial Frontal Gyrus_R (R.MeFG) | * | - |
| rs2738444 | CT | 5940 | 45 −36 42 | 28.40 | Inferior Parietal Lobule_R (R.IPL) | * | ** |
| rs11668477 | AG | - | - | - | None | ||
| rs12983082 | AC | - | - | - | None | ||
| LRP1 (Low-density lipoprotein receptor-related protein 1) | |||||||
| rs1140648 | AG | - | - | - | None | ||
| rs1799986 | CT | 1620 | 69 −27 −21 | 16.63 | Inferior Temporal Gyrus_R (R.ITG) | * | - |
| rs2306692 | CT | - | - | - | None | ||
| LRP8 (Low-density lipoprotein receptor-related protein 8) | |||||||
| rs5177 | CG | 3780 | 48 9 39 | 27.68 | Middle Frontal Gyrus_R (R.MFG) | * | - |
| 4698 | 30 24 18 | 18.91 | Insula_R (R.INS) | * | - | ||
| 4779 | 36 −24 54 | 17.88 | Precentral Gyrus_R (R.PreCG) | * | - | ||
| 4131 | −9 36 −15 | 16.36 | Medial Frontal Gyrus_B (B.MeFG) | * | - | ||
| rs3737983 | CT | 1296 | 18 36 51 | 14.93 | Superior Frontal Gyrus_R (R.SFG) | * | - |
| rs3820198 | GT | 3483 | −30 6 3 | 14.34 | Putamen_L (L.Put) | * | - |
| MTHFR(Methylenetetrahydrofolate reductase) | |||||||
| rs1801133 | CT | 1404 | −24 −84 15 | 8.49 | Middle Occipital Gyrus_L (L.MOG) | * | - |
| PLAU (Urokinase-plasminogen activator) | |||||||
| rs2227564 | CT | - | - | - | None | ||
| SOAT1 (Sortilin-related receptor) | |||||||
| rs1044925 | AC | - | - | - | None | ||
| rs2862616 | CT | - | - | - | None | ||
| rs3753526 | CG | 2916 | −39 27 3 | 22.29 | Inferior Frontal Gyrus_L (L.IFG) | * | - |
Abbreviations: R= right; L=left; B=Bilateral; Cluster size is in mm3; MNI: Montreal Neurological Institute.
*
Remained statistically significant after correcting for the imaging space (the statistical threshold was set at P < 0.005 and a cluster size of 1296 mm3, which corresponds to a corrected P < 0.05).
**
Remained statistically significant after correcting for the imaging space and across multiple SNPs, P < 0.05 [i.e., the original P-value was set at P < 0.0003 (0.005/15) with a cluster size of 1296 mm3].