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. 2016 Feb 11;7(13):15356–15368. doi: 10.18632/oncotarget.7324

Figure 2. G-MDSC exo attenuate the severity of DSS-induced colitis.

Figure 2

Murine experimental colitis was induced in C57BL/6 mice (n = 10/group) by providing 2.5% DSS solution in their drinking water for 10 days. Mice received i.p. injections with exosomes (30 μg/mouse/injection) on days 2, 4, and 6. (A) Disease activity was determined daily as described in the methods. Mice were sacrificed on day 8 by eye bloodletting followed by cervical dislocation. Colon sections obtained from mice were analyzed for their outward appearance (B), length (C), degree of inflammation (D) and H & E histologic scoring. (E) All data are presented as the mean ± SEM from one of three independent experiments. *p < 0.05, **p < 0.01; 1, G-MDSC exo-treated colitis mice versus colitis mice; 2, G-MDSC exo-treated colitis mice versus (G-MDSC+NN) exo-treated colitis mice, analysis with ANOVA and Q test. The mice of the control group had no DSS treatment. The mice of the colitis group had DSS treatment, while no exo treatment. All other experimental groups had DSS and different exos treatment.