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. 2016 Feb 2;7(13):15481–15491. doi: 10.18632/oncotarget.7139

Figure 5. PCGEM1-hnRNP A1 interaction suppresses, whereas PCGEM1-U2AF65 interaction enhances AR3 expression.

Figure 5

A. PCGEM1 interacts with hnRNP A1 and U2AF65, but not hnRNP C, as determined by RNA precipitation and Western. B. Suppression of U2AF causes reduction of AR variants (AR-v). C. No difference is seen for hnRNP A1 or U2AF expression between LNCaP and CWR22Rv1 cells in the presence or absence of androgen. D. AD enhances the interaction of PCGEM1 with hnRNP A1 and U2AF. E. While the interaction of hnRNP A1 with AR pre-mRNA is decreased after AD, the interaction of U2AF65 with AR pre-mRNA is increased. Values in D and E are means ± SE (n = 3). **, p < 0.01, two-sided two-sample t test.