Figure 6. Tumorigenic potential of human renal RCC-41-PDX-2 and RCC-41-PDX-2 subsets in SCID mice.

(A) Tumor formation of unsorted RCC-41-PDX-2, and freshly sorted RCC-41-PDX-2/CD133⁻ and RCC-41-PDX-2/CD133⁺ cells in SCID mice as a function of number of injected cells 10² and 10³ cells of each cell subtype were subcutaneously injected into SCID mice (n = 4 per group). Represented is the time for evaluation of tumor volume (mm³). Data are representative of 3 independent experiments with similar results. (B) Representation of tumor growth rate using survival curve. Death corresponds to a xenografted tumor reaching 1500 mm³. Data are representative of 3 independent experiments with similar results. *and **in (C) indicates respectively p < 0.05 and p < 0.005 by the log-rank test.