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. 2016 Jan 20;7(13):15554–15565. doi: 10.18632/oncotarget.6952

Figure 2. α-LA represses the activation of TGF-β1 and pro-fibrotic markers by radiation, in vivo and in vitro.

Figure 2

(A) α-LA inhibits the expression of TGF-β1-mediated fibrotic markers in the mouse RIF model. The mouse skin tissue was analyzed by immunohistochemistry (IHC) using the indicated antibodies. (B) α-LA blocked radiation-induced TGF-β1 expression, which was measured by TGF-β1 ELISA assay kits. The results were shown as mean ± S.D. calculated from three independent experiments. *p < 0.05. (C) α-LA attenuates the expression of pro-fibrotic markers in the mouse fibroblast NIH-3T3 cells. Cell lysates were analyzed by immunoblotting using the indicated antibodies.