Table 4. The prognostic significance of CA-125 normalization in ovarian CCC.

CA-125 normalization	No. (%)	FIGO stage (%)			CRS (%)			RFS		OS
		I+II	III+IV	P valuea	Optimal	Suboptimal	P valueb	5-year RFS(%)	P valuec	5-year OS(%)	P valuec
Pretreament	76 (20.3)	63 (82.9)	13 (17.1)	Referrence	76 (100)	0 (0)	Referrence	90.1	Referrence	94.0	Referrence
Between cycles 1 and 2	69 (18.4)	55 (79.7)	14 (20.3)	0.623	66 (95.7)	3 (4.3)	0.103	82.1	0.327	95.2	0.654
Between cycles 2 and 3	63 (16.8)	42 (66.7)	21 (33.3)	0.027	57 (90.5)	6 (9.5)	0.008	76.2	0.013	88.7	0.030
Between cycles 3 and 4	50 (13.3)	30 (60.0)	20 (40.0)	0.004	45 (90.0)	5 (10.0)	0.009	51.0	<0.001	79.0	0.003
Between cycles 4 and 6	48 (12.8)	21 (43.8)	27 (56.1)	<0.001	42 (87.5)	6 (12.5)	0.003	15.2	<0.001	64.4	<0.001
After 6 cycles	44 (11.7)	12 (27.3)	32 (72.7)	<0.001	38 (86.4)	6 (13.6)	0.002	2.3	<0.001	50.1	<0.001
No normalized	25 (6.7)	0 (0)	25 (100)	<0.001b	13 (52.0)	12 (48.0)	<0.001	-	-	36.7	<0.001

Note:

^aChi-square test

^bFisher's exact test

^CLog rank test.