Figure 4. LILRB3 and -A6 polymorphisms influence cellular recognition of mechanically damaged breast cancer cells.

Parental 2B4 reporter cells (2B4), and 2B4 cells transfected with the naturally occurring LILRB3 and LILRA6 variants A. and chimeric LILRB3/A6 sequences B. were used in co-culture with epithelial MCF-7 (striped bars) and non-epithelial HEK-293T (white bars) target cells. Mean and standard deviation values from 6 replicate experiments are shown. LILRB3/A6 molecules were cross-linked with a monoclonal antibody specific for the HA tag introduced into the N-terminus of the LILR during construction.