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. 2016 Feb 8;7(13):15648–15661. doi: 10.18632/oncotarget.7255

Figure 4. Effects on apoptosis and proliferation of HGSC cell lines after specific inhibition of CK2 in vitro.

Figure 4

Apoptotic and proliferative effect of CK2 inhibitor CX-4945 on A. IGROV-1 and SKOV3ip1 cells, in a dose dependent manner by Western blot analysis of apoptotic marker cleaved PARP and by cell numbers on plastic over a period of 6 days, and B. representative pictures of H&E stained sections in a 3D model after 6 days treatment, respectively. C. Quantification of cell growth inhibition and D. mRNA expression of cytokines and growth factors after treatment of SKOV3ip1 cells with CX-4945 in the 3D model (mean ± SEM, **, P<0.01, *, P<0.05).