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. 2016 Feb 17;7(13):15678–15689. doi: 10.18632/oncotarget.7463

Figure 3. RGMB gene manipulation alters lung cancer metastasis in vivo.

Figure 3

(A) Repression of RGMB increases migration of tumor cells into the lung. GFP-labeled tumor cells observed with a two-photon microscope are shown (scale bar = 200 μm). (B) Representative image showing metastatic tumor loci that formed in the lungs of mice injected with RGMB-knockdown or vector control A-549 cells. The bar graph shows counting of the tumor loci size using Image J in three fields per slide. (C) Metastatic lung cancer cells detected by flow cytometry. (D) Detection of metastatic RGMB-knockdown cells in different organs compared to control cells.