Table 2. Stratification analysis for the association between MUC1 rs4072037 A > G polymorphism and GC risk in an Eastern Chinese population.
Variables | rs4072037 (cases/controls) | Crude OR (95% CI) | P | Adjusted ORa (95% CI) | Pa | |
---|---|---|---|---|---|---|
AG/AA | GG | |||||
Median age, yr | ||||||
≤ 59 | 564/574 | 14/32 | 0.45 (0.24–0.84) | 0.013 | 0.45 (0.24–0.85) | 0.014 |
> 59 | 528/550 | 18/36 | 0.52 (0.29–0.93) | 0.027 | 0.51 (0.28–0.91) | 0.023 |
Sex | ||||||
Males | 779/773 | 21/52 | 0.40 (0.24–0.67) | 0.0005 | 0.40 (0.24–0.68) | 0.0006 |
Females | 313/351 | 11/16 | 0.77 (0.35–1.69) | 0.515 | 0.81 (0.37–1.78) | 0.591 |
Smoking status | ||||||
Never | 664/574 | 21/32 | 0.57 (0.32–1.00) | 0.048 | 0.55 (0.31–0.98) | 0.041 |
Ever | 428/550 | 11/36 | 0.39 (0.20–0.78) | 0.008 | 0.40 (0.20–0.81) | 0.010 |
Pack-year | ||||||
0 | 664/574 | 21/32 | 0.57 (0.32–1.00) | 0.048 | 0.55 (0.31–0.98) | 0.041 |
≤ 25 (mean) | 222/332 | 5/21 | 0.36 (0.13–0.96) | 0.041 | 0.36 (0.13–0.97) | 0.044 |
> 25 (mean) | 206/218 | 6/15 | 0.42 (0.16–1.11) | 0.081 | 0.48 (0.18–1.27) | 0.137 |
Drinking status | ||||||
Never | 828/804 | 26/44 | 0.57 (0.35–0.94) | 0.028 | 0.57 (0.35–0.94) | 0.027 |
Ever | 264/320 | 6/24 | 0.30 (0.12–0.75) | 0.010 | 0.31 (0.12–0.77) | 0.011 |
Tumor site | ||||||
GCA | 297/1124 | 8/68 | 0.45 (0.21–0.94) | 0.033 | 0.42 (0.20–0.89) | 0.024 |
NGCA | 795/1124 | 24/68 | 0.50 (0.31–0.80) | 0.004 | 0.50 (0.31–0.81) | 0.005 |
Adjusted for age, sex, smoking and drinking status in logistic regression models.