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IHC quantification of proliferation (Ki67) and apoptosis (cleaved caspase-3) in CNPC A., (n = 6 mice per group, and CRPC B., (n = 5 mice per group). Values represent mean ± s.e. C. Representative images of H&E stained CNPC or CRPC tumor from control and AZD5363 treated mice and their corresponding serial sections immunostained with Ki67and cleaved caspase-3.
