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. 2016 Jan 25;7(13):16325–16337. doi: 10.18632/oncotarget.7017

Figure 4. SKA2 is involved in CREB-regulated cell proliferation.

Figure 4

The mRNA and protein levels of SKA2 in RCC cells were significantly higher than HK-2 cell (A). After cells were transfected with siSKA2, the mRNA levels were significantly decreased (B), cell proliferation was inhibited (C). However, overexpression of CREB in OS-RC-2 cells co-transfected with pCI-neo/CREB (D), reversed siSKA2-reduced mRNA level (E), protein levels (F), cell growth (G) and cell division (H). Data are shown as mean ± SD from three independent experiments. *P < 0.05, **P < 0.01 versus HK-2 cell or siNC treatment. Scale bar, 10 μm.