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. 2016 Jan 25;7(13):16325–16337. doi: 10.18632/oncotarget.7017

Figure 5. Down-regulation of CREB suppresses xenograft tumor formation and reduces SKA2 expression in vivo.

Figure 5

Specific shCREB treatment induced a significant decrease of CREB mRNA and protein levels in OS-RC-2 cells (A). Smaller xenograft tumor formation was shown in shCREB treatment (B), and the average weights of tumors was lower (C) as compared with nude mice injected with OS-RC-2 cells containing scramble. IHC staining showed that the staining score for SKA2 was also lower than in controls (D). Furthermore, the SKA2 protein expression (E) and mRNA level (F) was significantly decreased compared with controls. Data are shown as mean ± SD. *P < 0.05, **P < 0.01 versus scramble. Representative images were captured at a magnification of × 200.