Table 5. AUC, sensitivity, specificity, PPV and NPV of IgA-gH/gL and EBV DNA in IgA-VCA-negative NPC patients in the validation cohort.

Test	AUC (95%)	pa	Sensitivity		pb	Specificity		pb	PPV		pc	NPV		pc
			%	95% CI		%	95% CI		%	95% CI		%	95% CI
gH/gL	0.835 (0.737-0.934)		76.9	60.7-93.1		80.3	73.8-86.9		41.7	27.8-55.6		95.0	91.1-98.9
EBV DNA	0.740 (0.612-0.867)		50.0	30.8-69.2		96.5	93.5-99.5		72.2	51.5-92.9		91.3	86.8-95.8
gH/gL vs. EBV DNA		NS			NS			<0.001			0.027			NS

PPV, positive predictive value; NPV, negative predictive value; NS, not significant; gH/gL, enzyme-linked immunosorbent assay detection of IgA antibodies against EBV glycoprotein complex gH/gL; VCA, immunofluorescence assay for IgA antibodies against viral capsid antigen; EBV DNA, qPCR test for plasma circulating EBV DNA.

^aZ test.

^bMcNemar's paired-sample test.

^cChi-squared test.