Table 4. Analysis of the progression-free survival based on the different evolution patterns of gliomas.
| Histology | total | Median PFS (days) | IDH status in initial tumors | IDH status in relapse tumors | p value |
|---|---|---|---|---|---|
| LGG→LGG | 29 | 802 | 20/27 | 20/28 | |
| LGG→AG | 35 | 830 | 20/34 | 21/34 | |
| LGG→GBM | 36 | 835 | 26/35 | 28/35 | |
| AG→AG | 20 | 611 | 10/20 | 12/20 | 0.0067 |
| AG→GBM | 22 | 365 | 10/22 | 10/22 | |
| GBM→GBM | 54 | 395 | 8/53 | 8/52 |
Abbreviations: PFS, progression-free survival; LGG, low grade glioma; AG, anaplastic glioma; GBM, glioblastoma; IDH, isocitrate dehydrogenase, ATRX, alpha-thalassemia/mental retardation, X-linked.