Skip to main content
. 2016 Feb 24;7(13):16479–16489. doi: 10.18632/oncotarget.7660

Figure 1. Schematic illustration of our approach to construct CVV and its higher cancer selectivity.

Figure 1

(A) We engineered a cancer-favoring virus (CVV) from the Wyeth strain of vaccinia virus. (B) Viral replication assay showing that CVV deficient of vTk replicated at lower levels at 24 h post-infection, but showed higher replication rates than EVV and WT. (C) CVV shows enhanced suppression of tumor size in CT26 xenograft mice compared to that observed in mice administered PBS, WT or EVV (n = 6, *p < 0.05 vs. PBS). (D) CVV-biodistribution results at 2 weeks post-intraperitoneal injection in HT29-bearing mice, showing that CVV selectively infected tumor mass. (E) CVV showed higher infectivity in colorectal cancer cell lines than in normal mouse embryonic fibroblasts.