Table 1. Exonic structure of MTAP-ANRIL gene fusions observed in the melanoma cell lines / tumors analyzed.
| Cell line/tumor | MTAP | ANRIL | Deletion type | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Ex 4 | Ex 5 | Ex 6 | Ex 7 | Ex 8 | Ex 1 | Ex 2 | Ex 3 | Ex 4 | Ex 5 | Ex 6 | ||
| MaMel-30 | ✓ | ✓ | ✓ | ✓ | ✓ | ✓ | HD | |||||
| ✓ | ✓ | ✓ | ✓ | ✓ | ||||||||
| MaMel-95 | ✓ | ✓ | ✓ | ✓ | ✓ | HD | ||||||
| MaMel-13 | ✓ | ✓ | ✓ | ✓ | ✓ | ✓ | LOH | |||||
| MaMel-122 | ✓ | ✓ | ✓ | ✓ | HD | |||||||
| UKRV-Mel-22b | ✓ | ✓ | ✓ | ✓ | LOH | |||||||
| Ma-Mel-66a | ✓ | ✓ | ✓ | ✓ | ✓ | LOH | ||||||
| Ma-Mel-83 | ✓ | ✓ | ✓ | ✓ | ✓ | ✓ | HD | |||||
| Ma-Mel-100 | ✓ | ✓ | ✓ | LOH | ||||||||
| Ma-Mel-24 | ✓ | ✓ | ✓ | ✓ | ✓ | LOH | ||||||
| Ma-Mel-61b | ✓ | ✓ | ✓ | ✓ | ✓ | LOH | ||||||
| UKRV-Mel-20c | ✓ | ✓ | ✓ | ✓ | ✓ | LOH | ||||||
| UKRV-Mel-32 | ✓ | ✓ | ✓ | ✓ | ✓ | HD | ||||||
| UKRV-Mel-22 | ✓ | ✓ | ✓ | ✓ | ✓ | ✓ | HD | |||||
| Tumor-1 | ✓ | ✓ | ✓ | ✓ | ✓ | LOH | ||||||
| Tumor-2 | ✓+ intron 4 | ✓ | LOH | |||||||||
| ✓ | ✓ | ✓ | ✓ | |||||||||
| ✓ | ✓ | ✓ + intron 6 | ✓ | |||||||||
Ex: exon number in the respective gene, HD: Homozygous deletion, LOH: Loss of heterozygosity.
The sequence data for the full length and partial transcripts have been submitted to the GenBank databases under accession numbers KT386339-KT386352.