. 2016 Feb 24;7(13):16505–16516. doi: 10.18632/oncotarget.7663

Table 4. Correlation between the clinicopathologic characteristics and CDH1 expression (n = 84).

Clinicopathological parameters	No.of patients	Membrane CDH1 (n, %)			Cytoplasmic CDH1 (n, %)
Clinicopathological parameters	No.of patients	Low	High	P-value	Low	High	P-value
Cases	84	31 (36.9)	53 (63.1)		56 (66.7)	28 (33.3)
Age (years)
≤ 60	39	17 (43.6)	22 (56.4)	0.237^a	26 (66.7)	13 (33.3)	1.000^a
> 60	45	14 (31.1)	31 (68.9)	0.237^a	30 (66.7)	15 (33.3)	1.000^a
Gender
Male	51	21 (41.2)	30 (58.8)	0.313^a	34 (66.7)	17 (33.3)	1.000^a
Female	33	10 (30.3)	23 (69.7)	0.313^a	22 (33.3)	11 (33.3)	1.000^a
Tumor location
Head, neck	56	24 (42.9)	32 (57.1)	0.110^a	35 (62.5)	21 (37.5)	0.252^a
Body, tail	28	7 (25.0)	21 (75.0)	0.110^a	21 (75.0)	7 (25.0)	0.252^a
Tumor size (cm)
≤ 3	25	9 (36.0)	16 (64.0)	0.911^a	18 (72.0)	7 (28.0)	0.500^a
> 3	59	22 (37.3)	37 (62.7)	0.911^a	38 (64.4)	21 (35.6)	0.500^a
Tumor differentiation
Well, moderate	57	21 (36.8)	36 (63.2)	0.986^a	40 (70.2)	17 (29.8)	0.322^a
Poor	27	10 (37.0)	17 (63.0)	0.986^a	16 (59.3)	11 (40.7)	0.322^a
Invasion depth
T1 + T2	71	27(38.0)	44(62.0)	0.618^a	49 (69.0)	22 (31.0)	0.286^a
T3 + T4	13	4(30.8)	9(69.2)	0.618^a	7 (53.8)	6 (46.2)	0.286^a
Lymph nodes metastasis
N0 (negative)	51	14 (27.5)	37 (72.5)	0.026^a ^*	43 (84.3)	8 (15.7)	< 0.001^a ^*
N1 (positive)	33	17 (51.5)	16 (48.5)	0.026^a ^*	13 (39.4)	20 (60.6)	< 0.001^a ^*
Distant metastasis
Absent	82	29 (35.4)	53 (64.6)	0.133^b	56 (68.3)	26 (31.7)	0.108^b
Present	2	2 (100)	0 (0)	0.133^b	0 (0)	2 (100)	0.108^b
Clinical stage
Early stages (≤ IIa)	49	13(26.5)	36(73.5)	0.020^a ^*	43(87.8)	6(12.2)	< 0.001^a ^*
Advanced stages (> IIa)	35	18(51.4)	17(48.6)	0.020^a ^*	13(37.1)	22(62.9)	< 0.001^a ^*
Abdominal pain
Absent	38	13 (34.2)	25 (65.8)	0.642^a	22 (57.9)	16 (42.1)	0.121^a
Present	46	18 (39.1)	28 (60.9)	0.642^a	34 (73.9)	12 (26.1)	0.121^a
Jaundice
Absent	69	23 (33.3)	46 (66.7)	0.146^a	47 (68.1)	22 (31.9)	0.546^a
Present	15	8 (53.3)	7 (46.7)	0.146^a	9 (60.0)	6 (40.0)	0.546^a
Nervous invasion
Negative	51	20 (39.2)	31 (60.8)	0.585^a	33 (64.7)	18 (35.3)	0.636^a
Positive	33	11 (33.3)	22 (66.7)	0.585^a	23 (69.7)	10 (30.3)	0.636^a

Chi-square test.

Fisher's exact test.

P < 0.05 indicates a significant association among the variables.