Table 6. Summary of univariate and multivariate Cox regression analysis of overall survival duration in all PCs.
| Clinicopathological parameters | Univariate analysis | Multivariate analysis | ||||
|---|---|---|---|---|---|---|
| HR | 95% CI | P-value | HR | 95% CI | P-value | |
| Membrane CDH1 | ||||||
| Low | 1 | |||||
| High | 0.500 | 0.290–0.861 | 0.012* | |||
| Cytoplasmic CDH1 | ||||||
| Low | 1 | 1 | ||||
| High | 2.996 | 1.725–5.204 | < 0.001* | 2.204 | 1.210–4.012 | 0.010* |
| Nuclear HDAC3 | ||||||
| Low | 1 | 1 | ||||
| High | 4.020 | 2.182–7.405 | < 0.001* | 3.033 | 1.572–5.852 | 0.001* |
| Cytoplasmic HDAC3 | ||||||
| Low | 1 | |||||
| High | 0.716 | 0.418–1.227 | 0.224 | |||
| Age (years) | ||||||
| ≤ 60 | 1 | |||||
| > 60 | 0.956 | 0.558–1.639 | 0.870 | |||
| Gender | ||||||
| Male | 1 | |||||
| Female | 0.531 | 0.295–0.957 | 0.035* | |||
| Tumor location | ||||||
| Head, neck | 1 | |||||
| Body, tail | 1.189 | 0.678–2.085 | 0.546 | |||
| Tumor size(cm) | ||||||
| ≤ 3 | 1 | |||||
| > 3 | 0.797 | 0.451–1.409 | 0.436 | |||
| Tumor differentiation | ||||||
| Well, moderate | 1 | 1 | ||||
| Poor | 2.077 | 1.192–3.620 | 0.010* | 2.119 | 1.210–3.711 | 0.009* |
| Invasion depth | ||||||
| T1 + T2 | 1 | |||||
| T3 + T4 | 0.983 | 0.463–2.088 | 0.965 | |||
| Lymph nodes metastasis | ||||||
| N0(negative) | 1 | |||||
| N1(positive) | 2.060 | 1.196–3.546 | 0.009* | |||
| Distant metastasis | ||||||
| Absent | 1 | |||||
| Present | 2.372 | 0.574–9.798 | 0.233 | |||
| Clinical stage | ||||||
| Early stages (≤ IIa) | 1 | |||||
| Advanced stages (> IIa) | 2.230 | 1.294–3.845 | 0.004* | |||
| Abdominal pain | ||||||
| Absent | 1 | |||||
| Present | 0.913 | 0.531–1.569 | 0.742 | |||
| Jaundice | ||||||
| Absent | 1 | |||||
| Present | 0.976 | 0.476–2.000 | 0.947 | |||
| Nervous invasion | ||||||
| Negative | 1 | |||||
| Positive | 1.168 | 0.678–2.012 | 0.576 | |||
HR hazard ratio, 95% CI 95% confidence interval.