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. 2016 Feb 27;7(13):16745–16759. doi: 10.18632/oncotarget.7778

Figure 4. Stable silencing of endogenous NOR1 induces EMT-like properties, migration, and invasion of HeLa cells via upregulation of slug.

Figure 4

(A) qRT-PCR analysis of the EMT transcription factor Slug and the epithelial markers keratin in HeLa cells with or without NOR1 expression. (B) Tumor cell migration assay. Stable silencing of NOR1 promotes migration of HeLa cells, but migration was alleviated by concomitant inhibition of Slug. (C) Tumor cell invasion assay. The same cells described in B were subjected to a tumor cell invasion assay. The graph provides summarized data of five independent experiments. (D) Scrambled shRNA or NOR1 shRNA along with Slug siRNA-transfected HeLa cells were subjected to western blotting. **P < 0.01, ***P < 0.001 compared to the control cells.