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. 2016 Feb 23;7(13):16866–16878. doi: 10.18632/oncotarget.7619

Figure 6. The effects of TGF-β and SKF96365 treatment in ERK and cell cycle-related signaling.

Figure 6

A. Western blot results showed that thapsigargin increased the phosphorylation of ERK1/2 and the treatment of TGF-β and SKF96365 decreased the phosphorylation of ERK1/2. B. The statistical results of p-ERK1/2 protein expression level referenced to total ERK1/2. C-D. TGF-β treatment for the indicated time induced the altered expression of cell cycle-related molecules p21 and cyclin E1. E-F. SKF96365 treatment for the indicated time induced the altered expression of cell cycle-related molecules p21 and cyclin E1. G. Model to depict STIM1 involving in TGF-β-induced suppression of cell proliferation in breast cancer cells. For this assay, bar graphs showed means ± SE for at least three independent experiments. Significance was assessed using one-way ANOVA with Bonferroni's multiple comparisons post-tests *P < 0.05.