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. 2016 Feb 26;7(13):17047–17059. doi: 10.18632/oncotarget.7742

Figure 2. KU-0060648 induces HCC cell apoptotic death.

Figure 2

HepG2 A-C. Huh-7 D. and KYN-2 (D) HCC cells, as well as the primary human HCC cells E. line-1/-2) and HL-7702 human hepatocytes F. pretreated with or without z-DEVD-fmk (“ZDEVD”, 40 μM) or z-VAD-fmk (“ZVAD”, 40 μM) for 1 h, were treated with applied concentrations of KU-0060648 (“KU”), cells were then cultured for indicated time, cell apoptosis was examined by the caspase-3 activity assay (A) or the Histone DNA apoptosis ELISA assay (B and F). Cell proliferation was tested by MTT assay (C-E). Experiments in this figure were repeated four times, with similar results obtained. n=5 for each repeat. Bars stand for mean ± SD #p < 0.05 vs. group “Ctrl”. *p < 0.05.