Figure 1. TIA1 protein overexpression and localization and its association with overall survival in primary ESCC tumors.

(A) Representative results of the immunohistochemical detection of TIA1 protein in normal mucosa, dysplasia, carcinoma in situ and advanced squamous cell carcinoma of the esophagus. Scale bars: 40 μm. (B) Representative results of the immunohistochemical detection of TIA1 and Ki-67 in serial sections of primary ESCC tissues. Scale bars: 40 μm. (C) Kaplan–Meier curves for overall survival rates of 143 ESCC patients according to the cytoplasmic (left) and nuclear (right) expression levels of TIA1 protein. The log-rank test was used for statistical analysis. Differences resulting in values of P < 0.05 are considered statistically significant.